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Gene Information
Gene ID:6422
Symbol:SFRP1
Full Name:secreted frizzled-related protein 1
Alias:FRP|FRP-1|FRP1|FrzA|SARP2
Organism:Homo sapiens (Human)
Chromosome:8
Genetic Location:8p12-p11.1
Physical Location:41238634-41286136 on NC_000008.9, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AF056087
Fold Change:-1.5, -1.4
Note:Differential Expression on the cDNA array (two fold changes are from two case groups)
Dataset Information
Name:11141048
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_003012.3NP_003003.3NC_000008.9 range: 41238634..41286136, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentTAS (9192640)
GO:0005515protein bindingMolecular FunctionIEA
GO:0006916anti-apoptosisBiological ProcessTAS (9391078)
GO:0007165signal transductionBiological ProcessTAS (9192640)
GO:0007275multicellular organismal developmentBiological ProcessIEA
GO:0009653anatomical structure morphogenesisBiological ProcessTAS (9192640)
GO:0016055Wnt receptor signaling pathwayBiological ProcessIEA
GO:0030154cell differentiationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:6422
HGNC:10776
Ensembl:ENSG00000104332
MIM:604156
HPRD:09165
HuGE Navigator:6422
dbSNP:SFRP1
GeneCard:SFRP1
AceView:SFRP1