ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Rab5a

Full Name:

RAB5A, member RAS oncogene family

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

9q11

Physical Location:

1492863-1516404 on NC_005108.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5868 Symbol (Name): RAB5A (RAB5A, member RAS oncogene family)

Ortholog Status:

The human GeneID 5868 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022692.1	NP_073183.1	NC_005108.2 range: 1492863..1516404, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0045121	membrane raft	Cellular Component	ISS
GO:0001726	ruffle	Cellular Component	ISS
GO:0030139	endocytic vesicle	Cellular Component	ISS
GO:0019717	synaptosome	Cellular Component	NAS (11795483)
GO:0005769	early endosome	Cellular Component	ISS
GO:0005886	plasma membrane	Cellular Component	ISS
GO:0019001	guanyl nucleotide binding	Molecular Function	ISS
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005525	GTP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0003924	GTPase activity	Molecular Function	ISS
GO:0007264	small GTPase mediated signal transduction	Biological Process	IEA
GO:0015031	protein transport	Biological Process	IEA
GO:0016192	vesicle-mediated transport	Biological Process	NAS (11795483)
GO:0006897	endocytosis	Biological Process	ISS