ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SLC30A5

Full Name:

solute carrier family 30 (zinc transporter), member 5

Alias:

FLJ12496|FLJ12756|MGC5499|ZNT5|ZNTL1|ZTL1|ZnT-5

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

5q12.1

Physical Location:

68425573-68461635 on NC_000005.8

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D5S647

66282906

Region:		66282906-76193808
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0030141	secretory granule	Cellular Component	IDA (10330022)
GO:0005624	membrane fraction	Cellular Component	NAS (11937503)
GO:0005794	Golgi apparatus	Cellular Component	IDA (10330022)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (11937503)
GO:0016324	apical plasma membrane	Cellular Component	IDA (11937503)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0008324	cation transmembrane transporter activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	NAS (11937503)
GO:0005385	zinc ion transmembrane transporter activity	Molecular Function	IDA (11937503)
GO:0006829	zinc ion transport	Biological Process	IDA (11937503)
GO:0010043	response to zinc ion	Biological Process	IDA (11937503)
GO:0010155	regulation of proton transport	Biological Process	NAS (11937503)
GO:0006824	cobalt ion transport	Biological Process	IDA (10330022\|11937503)
GO:0006812	cation transport	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA
GO:0006882	cellular zinc ion homeostasis	Biological Process	IDA (11937503)