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Gene Information
Gene ID:64924
Full Name:solute carrier family 30 (zinc transporter), member 5
Organism:Homo sapiens (Human)
Genetic Location:5q12.1
Physical Location:68425573-68461635 on NC_000005.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AA134752
Fold Change:0.66
P Value:2.00E-03
Tissue:Prefrontal cortex
Dataset Information
Tissue:Prefrontal cortex and nucleus accumbens
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.
Linkage Dataset
MarkerLODP valueLocation (bp)
D5S647  66282906
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_022902.2NP_075053.2NC_000005.8 range: 68425573..68461635
NM_024055.2NP_076960.1NC_000005.8 range: 68425573..68461635
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0030141secretory granuleCellular ComponentIDA (10330022)
GO:0005624membrane fractionCellular ComponentNAS (11937503)
GO:0005794Golgi apparatusCellular ComponentIDA (10330022)
GO:0005887integral to plasma membraneCellular ComponentTAS (11937503)
GO:0016324apical plasma membraneCellular ComponentIDA (11937503)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0008324cation transmembrane transporter activityMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionNAS (11937503)
GO:0005385zinc ion transmembrane transporter activityMolecular FunctionIDA (11937503)
GO:0006829zinc ion transportBiological ProcessIDA (11937503)
GO:0010043response to zinc ionBiological ProcessIDA (11937503)
GO:0010155regulation of proton transportBiological ProcessNAS (11937503)
GO:0006824cobalt ion transportBiological ProcessIDA (10330022|11937503)
GO:0006812cation transportBiological ProcessIEA
GO:0006810transportBiological ProcessIEA
GO:0006882cellular zinc ion homeostasisBiological ProcessIDA (11937503)
Other Database Cross Links
NCBI Entrez Gene:64924
HuGE Navigator:64924