ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

WNK1

Full Name:

WNK lysine deficient protein kinase 1

Alias:

KDP|KIAA0344|PHA2C|PRKWNK1|PSK

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

12p13.3

Physical Location:

732485-890878 on NC_000012.10

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 116477 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_018979.2	NP_061852.2	NC_000012.10 range: 732485..890878

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	NAS
GO:0005737	cytoplasm	Cellular Component	IDA (10660600)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IDA (10660600)
GO:0005515	protein binding	Molecular Function	IPI (15350218)
GO:0004860	protein kinase inhibitor activity	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA (10660600)
GO:0003674	molecular_function	Molecular Function	ND
GO:0006468	protein amino acid phosphorylation	Biological Process	IDA (10660600)
GO:0006811	ion transport	Biological Process	ISS
GO:0007243	protein kinase cascade	Biological Process	IDA (10660600)
GO:0008150	biological_process	Biological Process	ND
GO:0050794	regulation of cellular process	Biological Process	ISS