ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SLC8A3

Full Name:

solute carrier family 8 (sodium-calcium exchanger), member 3

Alias:

NCX3

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

14q24.1

Physical Location:

69580686-69725539 on NC_000014.7, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D14S258

69652605

Region:		67652605-71652605
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005432	calcium:sodium antiporter activity	Molecular Function	IEA
GO:0015297	antiporter activity	Molecular Function	IEA
GO:0031402	sodium ion binding	Molecular Function	IEA
GO:0005516	calmodulin binding	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0006814	sodium ion transport	Biological Process	IEA
GO:0007154	cell communication	Biological Process	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0006816	calcium ion transport	Biological Process	IEA