ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SLC10A1

Full Name:

solute carrier family 10 (sodium/bile acid cotransporter family), member 1

Alias:

NTCP|NTCP1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

14q24.1

Physical Location:

69312304-69333706 on NC_000014.7, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D14S258

69652605

Region:		67652605-71652605
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003049.2	NP_003040.1	NC_000014.7 range: 69312304..69333706, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	EXP (8132774)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (8132774)
GO:0008508	bile acid:sodium symporter activity	Molecular Function	EXP (8132774)
GO:0008508	bile acid:sodium symporter activity	Molecular Function	TAS (8132774)
GO:0015293	symporter activity	Molecular Function	IEA
GO:0031402	sodium ion binding	Molecular Function	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0006814	sodium ion transport	Biological Process	IEA
GO:0015711	organic anion transport	Biological Process	IEA