ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

BOLL

Full Name:

bol, boule-like (Drosophila)

Organism:

Homo sapiens (Human)

Chromosome:

2

Genetic Location:

2q33

Physical Location:

198299855-198359182 on NC_000002.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

BOLL

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S117

195326948

Region:		195326948-216757195
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_033030.5	NP_149019.1	NC_000002.10 range: 198299855..198359182, complement
NM_197970.2	NP_932074.1	NC_000002.10 range: 198299855..198359182, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (11390979)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0003723	RNA binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (16001084)
GO:0008494	translation activator activity	Molecular Function	IDA (16001084)
GO:0030154	cell differentiation	Biological Process	IEA
GO:0007283	spermatogenesis	Biological Process	IEA
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0007126	meiosis	Biological Process	IDA (12499397)
GO:0006417	regulation of translation	Biological Process	IEA
GO:0045948	positive regulation of translational initiation	Biological Process	IDA (16001084)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000152430

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: