ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Aurkaip1

Full Name:

aurora kinase A interacting protein 1

Alias:

0610033H09Rik|Aip|Akip

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 E2|4 83.0 cM

Physical Location:

155205754-155207167 on NC_000070.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 54998 Symbol (Name): AURKAIP1 (aurora kinase A interacting protein 1)

Ortholog Status:

The human GeneID 54998 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

0610033H09Rik

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap3q	Alcohol Preference Drinking	4	75	65-ter (cM)	4.6		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_025338.3	NP_079614.1	NC_000070.5 range: 155205754..155207167

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	ISS (12244051)
GO:0003674	molecular_function	Molecular Function	ND
GO:0016301	kinase activity	Molecular Function	IEA
GO:0045862	positive regulation of proteolysis	Biological Process	ISS (12244051)