ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

FSCN1

Full Name:

fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)

Alias:

FLJ38511|SNL|p55

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

7p22

Physical Location:

5598979-5612811 on NC_000007.12

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 14086 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D7S517

4464441

Region:		2464441-6464441
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003088.2	NP_003079.1	NC_000007.12 range: 5598979..5612811

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0015629	actin cytoskeleton	Cellular Component	TAS (8647875)
GO:0030674	protein binding, bridging	Molecular Function	IEA
GO:0051015	actin filament binding	Molecular Function	IEA
GO:0008283	cell proliferation	Biological Process	TAS (8068206)
GO:0030036	actin cytoskeleton organization and biogenesis	Biological Process	TAS (8647875)
GO:0051017	actin filament bundle formation	Biological Process	TAS (8647875)