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Gene Information
Gene ID:66277
Full Name:Kruppel-like factor 15
Organism:Mus musculus (Mouse)
Genetic Location:6 D1
Physical Location:90412619-90425202 on NC_000072.5
Gene Type:protein-coding
Human Ortholog:GeneID: 28999    Symbol (Name): KLF15 (Kruppel-like factor 15)
Ortholog Status:The human GeneID 28999 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AI852911
Fold Change:6.5, 1.7, 2.8, 1.6
Note:4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2
Dataset Information
Tissue:Whole brain
Phenotype:Acute ethanol response
Publication:Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_023184.3NP_075673.1NC_000072.5 range: 90412619..90425202
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIDA (12097321)
GO:0005622intracellularCellular ComponentIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0003676nucleic acid bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (12097321)
GO:0003700transcription factor activityMolecular FunctionIDA (12097321)
GO:0003677DNA bindingMolecular FunctionISS (15820306)
GO:0003677DNA bindingMolecular FunctionIDA (12097321)
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0015758glucose transportBiological ProcessIDA (12097321)
GO:0045893positive regulation of transcription, DNA-dependentBiological ProcessIDA (12097321)
Other Database Cross Links
NCBI Entrez Gene:66277