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Gene Information
Gene ID:664
Full Name:BCL2/adenovirus E1B 19kDa interacting protein 3
Organism:Homo sapiens (Human)
Genetic Location:10q26.3
Physical Location:133631193-133645424 on NC_000010.9, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:BQ002402
Fold Change:0.7
P Value:0.02
Tissue:Prefrontal cortex
Dataset Information
Tissue:Prefrontal cortex and nucleus accumbens
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.
Linkage Dataset
MarkerLODP valueLocation (bp)
D10S1651  132582544
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_004052.2NP_004043.2NC_000010.9 range: 133631193..133645424, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0030425dendriteCellular ComponentISS
GO:0031966mitochondrial membraneCellular ComponentIMP (9396766)
GO:0031307integral to mitochondrial outer membraneCellular ComponentIDA (10891486)
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0005739mitochondrionCellular ComponentTAS (9973195)
GO:0005739mitochondrionCellular ComponentIDA (7954800|9396766)
GO:0005737cytoplasmCellular ComponentISS
GO:0005654nucleoplasmCellular ComponentISS
GO:0005635nuclear envelopeCellular ComponentIDA (7954800)
GO:0005634nucleusCellular ComponentISS
GO:0031966mitochondrial membraneCellular ComponentIDA (10891486)
GO:0046982protein heterodimerization activityMolecular FunctionIDA (10381623)
GO:0042803protein homodimerization activityMolecular FunctionIDA (9396766|10381623)
GO:0045837negative regulation of membrane potentialBiological ProcessIDA (10891486)
GO:0046902regulation of mitochondrial membrane permeabilityBiological ProcessIDA (10891486)
GO:0051402neuron apoptosisBiological ProcessISS
GO:0001666response to hypoxiaBiological ProcessISS
GO:0008634negative regulation of survival gene product expressionBiological ProcessIDA (9973195)
GO:0008219cell deathBiological ProcessISS
GO:0008219cell deathBiological ProcessIDA (10891486)
GO:0006917induction of apoptosisBiological ProcessIDA (9396766|9973195|10381623)
GO:0006916anti-apoptosisBiological ProcessTAS (7954800)
GO:0006800oxygen and reactive oxygen species metabolic processBiological ProcessIDA (10891486)
GO:0006338chromatin remodelingBiological ProcessIDA (10891486)
GO:0006309DNA fragmentation during apoptosisBiological ProcessIDA (10891486)
GO:0051607defense response to virusBiological ProcessIDA (9973195)
Other Database Cross Links
NCBI Entrez Gene:664
HuGE Navigator:664