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Gene Information
Gene ID:6647
Symbol:SOD1
Full Name:superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))
Alias:ALS|ALS1|IPOA|SOD|homodimer
Organism:Homo sapiens (Human)
Chromosome:21
Genetic Location:21q22.1|21q22.11
Physical Location:31953805-31963114 on NC_000021.7
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:SOD1
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000454.4NP_000445.1NC_000021.7 range: 31953805..31963114
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentIDA (17077646|17324120)
GO:0043025cell somaCellular ComponentIDA (17324120)
GO:0005829cytosolCellular ComponentIDA (16790527)
GO:0005777peroxisomeCellular ComponentNAS (15766328)
GO:0005759mitochondrial matrixCellular ComponentNAS (17008312)
GO:0005739mitochondrionCellular ComponentIDA (16790527)
GO:0005737cytoplasmCellular ComponentIDA (9726962|11527942|17077646|17504823)
GO:0031012extracellular matrixCellular ComponentIDA (9699963)
GO:0005615extracellular spaceCellular ComponentIDA (7172448|9453566)
GO:0043234protein complexCellular ComponentIDA (17324120)
GO:0005634nucleusCellular ComponentIDA (9726962|17504823)
GO:0031410cytoplasmic vesicleCellular ComponentIDA (17077646)
GO:0032839dendrite cytoplasmCellular ComponentIDA (17324120)
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIDA (17381088)
GO:0030346protein phosphatase 2B bindingMolecular FunctionIDA (17324120)
GO:0016209antioxidant activityMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0042803protein homodimerization activityMolecular FunctionNAS (9726962|10837872)
GO:0051087chaperone bindingMolecular FunctionIPI (9726962)
GO:0004784superoxide dismutase activityMolecular FunctionIDA (15544046|17324120)
GO:0005507copper ion bindingMolecular FunctionIDA (17008312)
GO:0040014regulation of multicellular organism growthBiological ProcessISS
GO:0042542response to hydrogen peroxideBiological ProcessISS
GO:0043065positive regulation of apoptosisBiological ProcessIC (16790527)
GO:0042493response to drugBiological ProcessISS
GO:0043085positive regulation of catalytic activityBiological ProcessIDA (17324120)
GO:0043524negative regulation of neuron apoptosisBiological ProcessISS
GO:0045471response to ethanolBiological ProcessISS
GO:0060087relaxation of vascular smooth muscleBiological ProcessISS
GO:0060052neurofilament cytoskeleton organization and biogenesisBiological ProcessISS
GO:0060047heart contractionBiological ProcessIDA (9539776)
GO:0051881regulation of mitochondrial membrane potentialBiological ProcessIMP (16790527)
GO:0050665hydrogen peroxide biosynthetic processBiological ProcessISS
GO:0050665hydrogen peroxide biosynthetic processBiological ProcessIDA (15544046)
GO:0048678response to axon injuryBiological ProcessISS
GO:0048538thymus developmentBiological ProcessNAS (16716898)
GO:0046716muscle maintenanceBiological ProcessISS
GO:0046620regulation of organ growthBiological ProcessNAS (16716898)
GO:0045859regulation of protein kinase activityBiological ProcessIDA (16254550)
GO:0045541negative regulation of cholesterol biosynthetic processBiological ProcessIDA (15473258)
GO:0060088auditory receptor cell stereocilium organization and biogenesisBiological ProcessISS
GO:0033081regulation of T cell differentiation in the thymusBiological ProcessNAS (16716898)
GO:0006879cellular iron ion homeostasisBiological ProcessISS
GO:0006749glutathione metabolic processBiological ProcessISS
GO:0006309DNA fragmentation during apoptosisBiological ProcessISS
GO:0006302double-strand break repairBiological ProcessISS
GO:0000187activation of MAPK activityBiological ProcessISS
GO:0002262myeloid cell homeostasisBiological ProcessISS
GO:0001895retina homeostasisBiological ProcessISS
GO:0001890placenta developmentBiological ProcessNAS (12485882)
GO:0001819positive regulation of cytokine productionBiological ProcessIDA (15544046)
GO:0001541ovarian follicle developmentBiological ProcessISS
GO:0006979response to oxidative stressBiological ProcessIEP (15377661|17512922)
GO:0007283spermatogenesisBiological ProcessISS
GO:0007566embryo implantationBiological ProcessISS
GO:0032287myelin maintenance in the peripheral nervous systemBiological ProcessISS
GO:0019430removal of superoxide radicalsBiological ProcessISS
GO:0019226transmission of nerve impulseBiological ProcessISS
GO:0007569cell agingBiological ProcessIEP (15377661)
GO:0009408response to heatBiological ProcessISS
GO:0008217regulation of blood pressureBiological ProcessISS
GO:0007626locomotory behaviorBiological ProcessISS
GO:0007605sensory perception of soundBiological ProcessISS
GO:0007569cell agingBiological ProcessIMP (12871978)
GO:0007566embryo implantationBiological ProcessNAS (10920331)
GO:0000303response to superoxideBiological ProcessIDA (16790527)
Other Database Cross Links
NCBI Entrez Gene:6647
HGNC:11179
Ensembl:ENSG00000142168
MIM:147450
HPRD:00937
HuGE Navigator:6647
dbSNP:SOD1
GeneCard:SOD1
AceView:SOD1