ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Crnkl1

Full Name:

Crn, crooked neck-like 1 (Drosophila)

Alias:

1200013P10Rik|5730590A01Rik|C80326|crn

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 G1

Physical Location:

145743217-145760435 on NC_000068.6, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 51340 Symbol (Name): CRNKL1 (crooked neck pre-mRNA splicing factor-like 1 (Drosophila))

Ortholog Status:

The human GeneID 51340 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Crn
Fold Change:		1.46
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_025820.3	NP_080096.1	NC_000068.6 range: 145743217..145760435, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0005681	spliceosome	Cellular Component	ISS (12084575)
GO:0003674	molecular_function	Molecular Function	ND
GO:0005488	binding	Molecular Function	IEA
GO:0000398	nuclear mRNA splicing, via spliceosome	Biological Process	ISS (12084575)
GO:0006396	RNA processing	Biological Process	IEA
GO:0006397	mRNA processing	Biological Process	IEA
GO:0008380	RNA splicing	Biological Process	IEA