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Gene Information
Gene ID:6696
Symbol:SPP1
Full Name:secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
Alias:BNSP|BSPI|ETA-1|MGC110940|OPN
Organism:Homo sapiens (Human)
Chromosome:4
Genetic Location:4q21-q25
Physical Location:89115825-89123586 on NC_000004.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:R97904
Fold Change:0.65
P Value:8.00E-03
Tissue:Prefrontal cortex
Dataset Information
Name:15816859
Method:Microarray
Tissue:Prefrontal cortex and nucleus accumbens
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.
Gene Information
Original ID1:SPP1
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000582.2NP_000573.1NC_000004.10 range: 89115825..89123586
NM_001040058.1NP_001035147.1NC_000004.10 range: 89115825..89123586
NM_001040060.1NP_001035149.1NC_000004.10 range: 89115825..89123586
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentIEA
GO:0005125cytokine activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0001503ossificationBiological ProcessIEA
GO:0007155cell adhesionBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:6696
HGNC:11255
Ensembl:ENSG00000118785
MIM:166490
HPRD:01325
HuGE Navigator:6696
dbSNP:SPP1
GeneCard:SPP1
AceView:SPP1