ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

672

Symbol:

BRCA1

Full Name:

breast cancer 1, early onset

Alias:

BRCAI|BRCC1|IRIS|PSCP|RNF53

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q21

Physical Location:

38449839-38530993 on NC_000017.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

BRCA1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007294.2	NP_009225.1	NC_000017.9 range: 38449839..38530993, complement
NM_007295.2	NP_009226.1	NC_000017.9 range: 38449839..38530993, complement
NM_007296.2	NP_009227.1	NC_000017.9 range: 38449839..38530993, complement
NM_007297.2	NP_009228.1	NC_000017.9 range: 38449839..38530993, complement
NM_007298.2	NP_009229.1	NC_000017.9 range: 38449839..38530993, complement
NM_007299.2	NP_009230.1	NC_000017.9 range: 38449839..38530993, complement
NM_007300.2	NP_009231.1	NC_000017.9 range: 38449839..38530993, complement
NM_007302.2	NP_009233.1	NC_000017.9 range: 38449839..38530993, complement
NM_007303.2	NP_009234.1	NC_000017.9 range: 38449839..38530993, complement
NM_007304.2	NP_009235.2	NC_000017.9 range: 38449839..38530993, complement
NM_007305.2	NP_009236.1	NC_000017.9 range: 38449839..38530993, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005654	nucleoplasm	Cellular Component	EXP (10550055)
GO:0000151	ubiquitin ligase complex	Cellular Component	NAS (14976165)
GO:0005634	nucleus	Cellular Component	TAS (10918303)
GO:0031436	BRCA1-BARD1 complex	Cellular Component	IDA (15265711)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005622	intracellular	Cellular Component	IEA
GO:0008274	gamma-tubulin ring complex	Cellular Component	NAS (12214252)
GO:0005575	cellular_component	Cellular Component	ND
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	TAS (8944023)
GO:0015631	tubulin binding	Molecular Function	NAS (12214252)
GO:0019899	enzyme binding	Molecular Function	IPI (15965487)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0050681	androgen receptor binding	Molecular Function	NAS (15572661)
GO:0003674	molecular_function	Molecular Function	ND
GO:0003677	DNA binding	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	TAS (9662397)
GO:0003713	transcription coactivator activity	Molecular Function	NAS (15572661)
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	NAS (15905410)
GO:0005515	protein binding	Molecular Function	IEA
GO:0045739	positive regulation of DNA repair	Biological Process	NAS (12242698)
GO:0042127	regulation of cell proliferation	Biological Process	TAS (10918303)
GO:0042981	regulation of apoptosis	Biological Process	TAS (10918303)
GO:0000724	double-strand break repair via homologous recombination	Biological Process	IDA (17349954)
GO:0043627	response to estrogen stimulus	Biological Process	IDA (8895509)
GO:0046600	negative regulation of centriole replication	Biological Process	NAS (12214252)
GO:0045717	negative regulation of fatty acid biosynthetic process	Biological Process	IMP (16326698)
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	NAS (15572661)
GO:0045786	negative regulation of cell cycle	Biological Process	IEA
GO:0006281	DNA repair	Biological Process	IEA
GO:0031398	positive regulation of protein ubiquitination	Biological Process	IDA (15965487)
GO:0006301	postreplication repair	Biological Process	IDA (17349954)
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	TAS (10910365)
GO:0006359	regulation of transcription from RNA polymerase III promoter	Biological Process	TAS (10918303)
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	Biological Process	TAS (10918303)
GO:0007059	chromosome segregation	Biological Process	IMP (15965487)
GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis	Biological Process	IDA (14654789)
GO:0016481	negative regulation of transcription	Biological Process	IDA (16288014)
GO:0030521	androgen receptor signaling pathway	Biological Process	NAS (15572661)
GO:0000075	cell cycle checkpoint	Biological Process	NAS