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Gene Information
Gene ID:6729
Full Name:signal recognition particle 54kDa
Organism:Homo sapiens (Human)
Genetic Location:14q13.2
Physical Location:34521981-34568518 on NC_000014.7
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:SRP54
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Linkage Dataset
MarkerLODP valueLocation (bp)
D14S70  33528945
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_003136.2NP_003127.1NC_000014.7 range: 34521981..34568518
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005730nucleolusCellular ComponentIDA (10618370)
GO:0005737cytoplasmCellular ComponentIDA (10618370)
GO:0005786signal recognition particle, endoplasmic reticulum targetingCellular ComponentIEA
GO:0016607nuclear speckCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0017111nucleoside-triphosphatase activityMolecular FunctionIEA
GO:00083127S RNA bindingMolecular FunctionIDA (9511762)
GO:0043021ribonucleoprotein bindingMolecular FunctionIDA (9511762)
GO:0005525GTP bindingMolecular FunctionIEA
GO:0006614SRP-dependent cotranslational protein targeting to membraneBiological ProcessIC (9511762)
Other Database Cross Links
NCBI Entrez Gene:6729
HuGE Navigator:6729