ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SRP54

Full Name:

signal recognition particle 54kDa

Organism:

Homo sapiens (Human)

Chromosome:

14

Genetic Location:

14q13.2

Physical Location:

34521981-34568518 on NC_000014.7

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

SRP54

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D14S70

33528945

Region:		31528945-35528945
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003136.2	NP_003127.1	NC_000014.7 range: 34521981..34568518

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005730	nucleolus	Cellular Component	IDA (10618370)
GO:0005737	cytoplasm	Cellular Component	IDA (10618370)
GO:0005786	signal recognition particle, endoplasmic reticulum targeting	Cellular Component	IEA
GO:0016607	nuclear speck	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0017111	nucleoside-triphosphatase activity	Molecular Function	IEA
GO:0008312	7S RNA binding	Molecular Function	IDA (9511762)
GO:0043021	ribonucleoprotein binding	Molecular Function	IDA (9511762)
GO:0005525	GTP binding	Molecular Function	IEA
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	Biological Process	IC (9511762)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000100883

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: