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Gene Information
Gene ID:6745
Symbol:SSR1
Full Name:signal sequence receptor, alpha (translocon-associated protein alpha)
Alias:DKFZp781N23103|FLJ14232|FLJ22100|FLJ23034|FLJ78242|FLJ93042|TRAPA
Organism:Homo sapiens (Human)
Chromosome:6
Genetic Location:6p24.3
Physical Location:7232802-7258433 on NC_000006.10, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D6S1574  5957132
Region:3957132-7957132
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
MarkerLODP valueLocation (bp)
D6S309  8169921
Region:6169921-10169921
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_003144.3NP_003135.2NC_000006.10 range: 7232802..7258433, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005783endoplasmic reticulumCellular ComponentTAS (8050590)
GO:0005789endoplasmic reticulum membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentTAS (8050590)
GO:0005048signal sequence bindingMolecular FunctionTAS (8050590)
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0006613cotranslational protein targeting to membraneBiological ProcessTAS (8050590)
GO:0008284positive regulation of cell proliferationBiological ProcessTAS (10437777)
Other Database Cross Links
NCBI Entrez Gene:6745
HGNC:11323
Ensembl:ENSG00000124783
MIM:600868
HPRD:02924
HuGE Navigator:6745
dbSNP:SSR1
GeneCard:SSR1
AceView:SSR1