ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

VAMP1

Full Name:

vesicle-associated membrane protein 1 (synaptobrevin 1)

Alias:

DKFZp686H12131|SYB1|VAMP-1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

12p

Physical Location:

6441663-6450103 on NC_000012.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D12S99

5434815

Region:		3434815-7434815
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0045202	synapse	Cellular Component	IEA
GO:0030054	cell junction	Cellular Component	IEA
GO:0019867	outer membrane	Cellular Component	IEA
GO:0019717	synaptosome	Cellular Component	IEA
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0008021	synaptic vesicle	Cellular Component	NR
GO:0005887	integral to plasma membrane	Cellular Component	TAS (1976629)
GO:0005741	mitochondrial outer membrane	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0030659	cytoplasmic vesicle membrane	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IPI (9920726)
GO:0016192	vesicle-mediated transport	Biological Process	IEA