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Gene Information
Gene ID:685781
Symbol:Ddr2
Full Name:discoidin domain receptor family, member 2
Alias:Tyro10
Organism:Rattus norvegicus (Rat)
Chromosome:13
Genetic Location:13q24
Physical Location:85802057-85926414 on NC_005112.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 4921    Symbol (Name): DDR2 (discoidin domain receptor tyrosine kinase 2)
Ortholog Status:The human GeneID 4921 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Ddr2
Fold Change:-1.18
Tissue:Amygdala
Dataset Information
Name:17517326
Method:Microarray
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
XM_001065242.1XP_001065242.1NC_005112.2 range: 85802057..85926414, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0004714transmembrane receptor protein tyrosine kinase activityMolecular FunctionIEA
GO:0005518collagen bindingMolecular FunctionIDA (12220173)
GO:0005524ATP bindingMolecular FunctionIEA
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayBiological ProcessIEA
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayBiological ProcessISS
GO:0008284positive regulation of cell proliferationBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:685781
RGD:619855
Ensembl:ENSRNOG00000002881
dbSNP:Ddr2