ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ddr2

Full Name:

discoidin domain receptor family, member 2

Alias:

Tyro10

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

13q24

Physical Location:

85802057-85926414 on NC_005112.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4921 Symbol (Name): DDR2 (discoidin domain receptor tyrosine kinase 2)

Ortholog Status:

The human GeneID 4921 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_001065242.1	XP_001065242.1	NC_005112.2 range: 85802057..85926414, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function	IEA
GO:0005518	collagen binding	Molecular Function	IDA (12220173)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	IEA
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	ISS
GO:0008284	positive regulation of cell proliferation	Biological Process	ISS