ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TCEB1

Full Name:

transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)

Alias:

SIII

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

8q21.11

Physical Location:

75021187-75046899 on NC_000008.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		L34587
Fold Change:		1.4, 2.4
Note:		Differential expression on the oligonucleotide array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005648.2	NP_005639.1	NC_000008.9 range: 75021187..75046899, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005654	nucleoplasm	Cellular Component	EXP (12676794)
GO:0005829	cytosol	Cellular Component	EXP (14564014\|15781449)
GO:0003711	transcription elongation regulator activity	Molecular Function	NR
GO:0005515	protein binding	Molecular Function	IPI (10851083)
GO:0006350	transcription	Biological Process	IEA
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	TAS (7660129)
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA
GO:0006512	ubiquitin cycle	Biological Process	IEA