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Gene Information
Gene ID:6999
Symbol:TDO2
Full Name:tryptophan 2,3-dioxygenase
Alias:TDO|TPH2|TRPO
Organism:Homo sapiens (Human)
Chromosome:4
Genetic Location:4q31-q32
Physical Location:157044296-157060999 on NC_000004.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:TDO2
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
TDO21Alcoholism
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_005651.1NP_005642.1NC_000004.10 range: 157044296..157060999
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005829cytosolCellular ComponentEXP (8666386)
GO:0004833tryptophan 2,3-dioxygenase activityMolecular FunctionEXP (8666386)
GO:0004833tryptophan 2,3-dioxygenase activityMolecular FunctionTAS (8666386)
GO:0005506iron ion bindingMolecular FunctionIEA
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0006568tryptophan metabolic processBiological ProcessIEA
GO:0019674NAD metabolic processBiological ProcessEXP (14704851)
GO:0042133neurotransmitter metabolic processBiological ProcessNR
Other Database Cross Links
NCBI Entrez Gene:6999
HGNC:11708
Ensembl:ENSG00000151790
MIM:191070
HPRD:01847
HuGE Navigator:6999
dbSNP:TDO2
GeneCard:TDO2
AceView:TDO2