ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TFAP2A

Full Name:

transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)

Alias:

AP-2|AP-2alpha|AP2TF|TFAP2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

6p24

Physical Location:

10504901-10527782 on NC_000006.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D6S470

10133701

Region:		8133701-12133701
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IMP (12586840)
GO:0005634	nucleus	Cellular Component	IEA
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0046983	protein dimerization activity	Molecular Function	IDA (12072434)
GO:0003713	transcription coactivator activity	Molecular Function	TAS (8321221)
GO:0003705	RNA polymerase II transcription factor activity, enhancer binding	Molecular Function	NR
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	TAS (8321221)
GO:0007165	signal transduction	Biological Process	NR
GO:0007398	ectoderm development	Biological Process	TAS (8661133)
GO:0006350	transcription	Biological Process	IEA