ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

7040

Symbol:

TGFB1

Full Name:

transforming growth factor, beta 1

Alias:

CED|DPD1|TGFB

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

19q13.2|19q13.1

Physical Location:

46528490-46551655 on NC_000019.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

TGFB1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

Original ID	No. of Publications	Phenotype
TGFB1	2	Alcohol-Induced Disorders
TGFB1	1	Alcoholism
TGFB1	2	Alcohol-Related Disorders

HuGE Navigator Dataset

Name:		HuGE Navigator
Method:		Literature data mining
Publication:		Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:		HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000660.3	NP_000651.3	NC_000019.8 range: 46528490..46551655, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005578	proteinaceous extracellular matrix	Cellular Component	ISS
GO:0031093	platelet alpha granule lumen	Cellular Component	EXP (3457014)
GO:0005796	Golgi lumen	Cellular Component	EXP (3457014\|9934696)
GO:0005615	extracellular space	Cellular Component	ISS
GO:0005576	extracellular region	Cellular Component	EXP (9865696\|9934696\|11100470)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0008083	growth factor activity	Molecular Function	IEA
GO:0016563	transcription activator activity	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0005160	transforming growth factor beta receptor binding	Molecular Function	ISS
GO:0030308	negative regulation of cell growth	Biological Process	IDA (15334054)
GO:0019049	evasion of host defenses by virus	Biological Process	IDA (15334054)
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	Biological Process	IDA (15334054)
GO:0031575	G1/S transition checkpoint	Biological Process	IDA (15334054)
GO:0032967	positive regulation of collagen biosynthetic process	Biological Process	TAS (9639571)
GO:0035307	positive regulation of protein amino acid dephosphorylation	Biological Process	IDA (14555988)
GO:0042306	regulation of protein import into nucleus	Biological Process	ISS
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	ISS
GO:0045930	negative regulation of mitotic cell cycle	Biological Process	IDA (14555988)
GO:0048298	positive regulation of isotype switching to IgA isotypes	Biological Process	IDA (14988498)
GO:0048535	lymph node development	Biological Process	ISS
GO:0050680	negative regulation of epithelial cell proliferation	Biological Process	IMP (16943770)
GO:0001501	skeletal development	Biological Process	ISS
GO:0016481	negative regulation of transcription	Biological Process	IDA (15702480)
GO:0001837	epithelial to mesenchymal transition	Biological Process	TAS (14679171)
GO:0002248	connective tissue replacement during inflammatory response	Biological Process	TAS (9639571)
GO:0006468	protein amino acid phosphorylation	Biological Process	ISS
GO:0006754	ATP biosynthetic process	Biological Process	IDA (10513816)
GO:0006796	phosphate metabolic process	Biological Process	IDA (10513816)
GO:0006917	induction of apoptosis	Biological Process	IDA (15334054)
GO:0006954	inflammatory response	Biological Process	ISS
GO:0007050	cell cycle arrest	Biological Process	IDA (14555988)
GO:0007184	SMAD protein nuclear translocation	Biological Process	IDA (15334054)
GO:0008219	cell death	Biological Process	ISS
GO:0008284	positive regulation of cell proliferation	Biological Process	ISS
GO:0009887	organ morphogenesis	Biological Process	ISS
GO:0016202	regulation of striated muscle development	Biological Process	ISS
GO:0051101	regulation of DNA binding	Biological Process	ISS