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Gene Information
Gene ID:7098
Symbol:TLR3
Full Name:toll-like receptor 3
Alias:CD283
Organism:Homo sapiens (Human)
Chromosome:4
Genetic Location:4q35
Physical Location:187227302-187243245 on NC_000004.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:TLR3
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_003265.2NP_003256.1NC_000004.10 range: 187227302..187243245
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentNAS (12054664)
GO:0010008endosome membraneCellular ComponentIEA
GO:0010008endosome membraneCellular ComponentEXP (11607032|12609980|12692549|12855817|15064760)
GO:0005768endosomeCellular ComponentIEA
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0005789endoplasmic reticulum membraneCellular ComponentIEA
GO:0005887integral to plasma membraneCellular ComponentTAS (9435236)
GO:0003725double-stranded RNA bindingMolecular FunctionIDA (16111635)
GO:0005515protein bindingMolecular FunctionIEA
GO:0004888transmembrane receptor activityMolecular FunctionNAS (12054664)
GO:0003725double-stranded RNA bindingMolecular FunctionNAS (12054664)
GO:0045359positive regulation of interferon-beta biosynthetic processBiological ProcessIDA (16286015)
GO:0045356positive regulation of interferon-alpha biosynthetic processBiological ProcessIDA (16286015)
GO:0045087innate immune responseBiological ProcessIEA
GO:0045078positive regulation of interferon-gamma biosynthetic processBiological ProcessIDA (16286015)
GO:0045359positive regulation of interferon-beta biosynthetic processBiological ProcessIMP (12054664)
GO:0042742defense response to bacteriumBiological ProcessTAS (10426995)
GO:0009597detection of virusBiological ProcessNAS (12054664)
GO:0007250activation of NF-kappaB-inducing kinase activityBiological ProcessNAS (12054664)
GO:0007165signal transductionBiological ProcessTAS (9435236|10426995)
GO:0006972hyperosmotic responseBiological ProcessNAS (12054664)
GO:0006954inflammatory responseBiological ProcessIEA
GO:0045671negative regulation of osteoclast differentiationBiological ProcessNAS (12133979)
Other Database Cross Links
NCBI Entrez Gene:7098
HGNC:11849
Ensembl:ENSG00000164342
MIM:603029
HPRD:04324
HuGE Navigator:7098
dbSNP:TLR3
GeneCard:TLR3
AceView:TLR3