Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:7132
Full Name:tumor necrosis factor receptor superfamily, member 1A
Organism:Homo sapiens (Human)
Genetic Location:12p13.2
Physical Location:6308183-6321521 on NC_000012.10, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:TNFRSF1A
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Linkage Dataset
MarkerLODP valueLocation (bp)
D12S99  5434815
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001065.2NP_001056.1NC_000012.10 range: 6308183..6321521, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentIEA
GO:0005887integral to plasma membraneCellular ComponentTAS (1698610)
GO:0005576extracellular regionCellular ComponentNAS (12189246)
GO:0005886plasma membraneCellular ComponentEXP (2848815|7758105|12887920)
GO:0004872receptor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (9115275|11684708|15465831)
GO:0005031tumor necrosis factor receptor activityMolecular FunctionTAS (2158863)
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessISS
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeBiological ProcessIEP (12761501)
GO:0019221cytokine and chemokine mediated signaling pathwayBiological ProcessISS
GO:0007165signal transductionBiological ProcessIEA
GO:0006915apoptosisBiological ProcessIEA
GO:0006693prostaglandin metabolic processBiological ProcessISS
GO:0050729positive regulation of inflammatory responseBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:7132
HuGE Navigator:7132