ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TNFRSF1A

Full Name:

tumor necrosis factor receptor superfamily, member 1A

Alias:

CD120a|FPF|MGC19588|TBP1|TNF-R|TNF-R-I|TNF-R55|TNFAR|TNFR1|TNFR55|TNFR60|p55|p55-R|p60

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

12p13.2

Physical Location:

6308183-6321521 on NC_000012.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

TNFRSF1A

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D12S99

5434815

Region:		3434815-7434815
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001065.2	NP_001056.1	NC_000012.10 range: 6308183..6321521, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	TAS (1698610)
GO:0005576	extracellular region	Cellular Component	NAS (12189246)
GO:0005886	plasma membrane	Cellular Component	EXP (2848815\|7758105\|12887920)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (9115275\|11684708\|15465831)
GO:0005031	tumor necrosis factor receptor activity	Molecular Function	TAS (2158863)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	ISS
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	IEP (12761501)
GO:0019221	cytokine and chemokine mediated signaling pathway	Biological Process	ISS
GO:0007165	signal transduction	Biological Process	IEA
GO:0006915	apoptosis	Biological Process	IEA
GO:0006693	prostaglandin metabolic process	Biological Process	ISS
GO:0050729	positive regulation of inflammatory response	Biological Process	ISS