ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TP53BP2

Full Name:

tumor protein p53 binding protein, 2

Alias:

53BP2|ASPP2|BBP|PPP1R13A|p53BP2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1q42.1

Physical Location:

222034217-222100296 on NC_000001.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 209456 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AI123916
Fold Change:		-1.4, -1.5
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	TAS (15782125)
GO:0005070	SH3/SH2 adaptor activity	Molecular Function	TAS (8668206)
GO:0005515	protein binding	Molecular Function	IPI (11684014\|12694406\|14729977)
GO:0051059	NF-kappaB binding	Molecular Function	IPI (10498867)
GO:0006915	apoptosis	Biological Process	IEA
GO:0006917	induction of apoptosis	Biological Process	IDA (11684014)
GO:0007165	signal transduction	Biological Process	TAS (9748285)
GO:0045786	negative regulation of cell cycle	Biological Process	TAS (14729977)