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Gene Information
Gene ID:716
Full Name:complement component 1, s subcomponent
Organism:Homo sapiens (Human)
Genetic Location:12p13
Physical Location:7038277-7048596 on NC_000012.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:C1S
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Linkage Dataset
MarkerLODP valueLocation (bp)
D12S99  5434815
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001734.2NP_001725.1NC_000012.10 range: 7038277..7048596
NM_201442.1NP_958850.1NC_000012.10 range: 7038277..7048596
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentEXP (814163|1249422)
GO:0005576extracellular regionCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0001584rhodopsin-like receptor activityMolecular FunctionIEA
GO:0003674molecular_functionMolecular FunctionND
GO:0003816complement component C1s activityMolecular FunctionTAS (9856483)
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0008150biological_processBiological ProcessND
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIEA
GO:0006958complement activation, classical pathwayBiological ProcessIEA
GO:0006508proteolysisBiological ProcessIEA
GO:0045087innate immune responseBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:716
HuGE Navigator:716