ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TRPC4

Full Name:

transient receptor potential cation channel, subfamily C, member 4

Alias:

HTRP4|MGC119570|MGC119571|MGC119572|MGC119573|TRP4

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

13q13.1-q13.2

Physical Location:

37108794-37341934 on NC_000013.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D13S171

32151912

Region:		32151912-40979230
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_016179.1	NP_057263.1	NC_000013.9 range: 37108794..37341934, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0030863	cortical cytoskeleton	Cellular Component	IDA (16254212)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IDA (16254212)
GO:0005840	ribosome	Cellular Component	IEA
GO:0005622	intracellular	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IPI (16254212)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0015279	store-operated calcium channel activity	Molecular Function	IMP (16254212)
GO:0003735	structural constituent of ribosome	Molecular Function	IEA
GO:0005262	calcium channel activity	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0006816	calcium ion transport	Biological Process	TAS (8646775)
GO:0006412	translation	Biological Process	IEA
GO:0006816	calcium ion transport	Biological Process	IEA