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Gene Information
Gene ID:7223
Full Name:transient receptor potential cation channel, subfamily C, member 4
Organism:Homo sapiens (Human)
Genetic Location:13q13.1-q13.2
Physical Location:37108794-37341934 on NC_000013.9, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D13S171  32151912
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_016179.1NP_057263.1NC_000013.9 range: 37108794..37341934, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0030863cortical cytoskeletonCellular ComponentIDA (16254212)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentIDA (16254212)
GO:0005840ribosomeCellular ComponentIEA
GO:0005622intracellularCellular ComponentIEA
GO:0005515protein bindingMolecular FunctionIPI (16254212)
GO:0004872receptor activityMolecular FunctionIEA
GO:0005216ion channel activityMolecular FunctionIEA
GO:0015279store-operated calcium channel activityMolecular FunctionIMP (16254212)
GO:0003735structural constituent of ribosomeMolecular FunctionIEA
GO:0005262calcium channel activityMolecular FunctionIEA
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0006811ion transportBiological ProcessIEA
GO:0006816calcium ion transportBiological ProcessTAS (8646775)
GO:0006412translationBiological ProcessIEA
GO:0006816calcium ion transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:7223
HuGE Navigator:7223