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Gene Information
Gene ID:7248
Symbol:TSC1
Full Name:tuberous sclerosis 1
Alias:KIAA0243|LAM|MGC86987|TSC
Organism:Homo sapiens (Human)
Chromosome:9
Genetic Location:9q34
Physical Location:134756556-134809840 on NC_000009.10, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:TSC1
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000368.3NP_000359.1NC_000009.10 range: 134756556..134809840, complement
NM_001008567.1NP_001008567.1NC_000009.10 range: 134756556..134809840, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0030027lamellipodiumCellular ComponentIDA (10806479)
GO:0016020membraneCellular ComponentIEA
GO:0033596TSC1-TSC2 complexCellular ComponentIDA (9580671)
GO:0005938cell cortexCellular ComponentIDA (10806479)
GO:0005884actin filamentCellular ComponentIDA (10806479)
GO:0005829cytosolCellular ComponentIDA (10585443)
GO:0005829cytosolCellular ComponentEXP (15314020|15589136)
GO:0005737cytoplasmCellular ComponentIDA (9580671)
GO:0005624membrane fractionCellular ComponentIDA (16636147)
GO:0051087chaperone bindingMolecular FunctionIPI (10585443)
GO:0047485protein N-terminus bindingMolecular FunctionIPI (10806479|12226091)
GO:0043666regulation of phosphoprotein phosphatase activityBiological ProcessIMP (17308101)
GO:0045786negative regulation of cell cycleBiological ProcessIEA
GO:0051492regulation of stress fiber formationBiological ProcessIDA (10806479)
GO:0032868response to insulin stimulusBiological ProcessIDA (16996505)
GO:0032862activation of Rho GTPase activityBiological ProcessIDA (10806479)
GO:0032007negative regulation of TOR signaling pathwayBiological ProcessIMP (17308101)
GO:0031397negative regulation of protein ubiquitinationBiological ProcessIDA (11175345)
GO:0001952regulation of cell-matrix adhesionBiological ProcessIMP (10806479)
GO:0017148negative regulation of translationBiological ProcessIMP (17308101)
GO:0008285negative regulation of cell proliferationBiological ProcessIMP (10915759)
GO:0006407rRNA export from nucleusBiological ProcessIMP (17308101)
GO:0051894positive regulation of focal adhesion formationBiological ProcessIDA (10806479)
Other Database Cross Links
NCBI Entrez Gene:7248
HGNC:12362
Ensembl:ENSG00000165699
MIM:605284
HPRD:05594
HuGE Navigator:7248
dbSNP:TSC1
GeneCard:TSC1
AceView:TSC1