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Gene Information
Gene ID:7249
Symbol:TSC2
Full Name:tuberous sclerosis 2
Alias:FLJ43106|LAM|TSC4
Organism:Homo sapiens (Human)
Chromosome:16
Genetic Location:16p13.3
Physical Location:2037990-2078713 on NC_000016.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:TSC2
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000548.3NP_000539.2NC_000016.8 range: 2037990..2078713
NM_001077183.1NP_001070651.1NC_000016.8 range: 2037990..2078713
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005794Golgi apparatusCellular ComponentIDA (10585443)
GO:0005794Golgi apparatusCellular ComponentIDA (8806680)
GO:0005737cytoplasmCellular ComponentIDA (17114346)
GO:0005737cytoplasmCellular ComponentIDA (9580671|16636147)
GO:0005634nucleusCellular ComponentIDA (16636147)
GO:0005634nucleusCellular ComponentIDA (17114346)
GO:0005624membrane fractionCellular ComponentIDA (16636147)
GO:0005622intracellularCellular ComponentIEA
GO:0005829cytosolCellular ComponentIDA (10585443)
GO:0048471perinuclear region of cytoplasmCellular ComponentIDA (8806680)
GO:0016020membraneCellular ComponentIEA
GO:0033596TSC1-TSC2 complexCellular ComponentIDA (9580671)
GO:0005829cytosolCellular ComponentEXP (15314020|15589136)
GO:0042803protein homodimerization activityMolecular FunctionIPI (10585443)
GO:0005515protein bindingMolecular FunctionIPI (9580671|10585443|12364343)
GO:0005096GTPase activator activityMolecular FunctionIDA (9045618)
GO:0005488bindingMolecular FunctionIEA
GO:0005096GTPase activator activityMolecular FunctionIEA
GO:0043547positive regulation of GTPase activityBiological ProcessIEA
GO:0045786negative regulation of cell cycleBiological ProcessIEA
GO:0046626regulation of insulin receptor signaling pathwayBiological ProcessISS
GO:0048009insulin-like growth factor receptor signaling pathwayBiological ProcessISS
GO:0050918positive chemotaxisBiological ProcessISS
GO:0051056regulation of small GTPase mediated signal transductionBiological ProcessIEA
GO:0001843neural tube closureBiological ProcessISS
GO:0030100regulation of endocytosisBiological ProcessISS
GO:0014067negative regulation of phosphoinositide 3-kinase cascadeBiological ProcessISS
GO:0008285negative regulation of cell proliferationBiological ProcessISS
GO:0008104protein localizationBiological ProcessISS
GO:0007507heart developmentBiological ProcessISS
GO:0006606protein import into nucleusBiological ProcessISS
GO:0006469negative regulation of protein kinase activityBiological ProcessISS
GO:0051898negative regulation of protein kinase B signaling cascadeBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:7249
HGNC:12363
Ensembl:ENSG00000103197
MIM:191092
HPRD:01850
HuGE Navigator:7249
dbSNP:TSC2
GeneCard:TSC2
AceView:TSC2