ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Full Name:

complement component 5

Alias:

CPAMD4|FLJ17816|FLJ17822|MGC142298

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

9q33-q34

Physical Location:

122754433-122852374 on NC_000009.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 15139 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D9S934

2.28

0.0006

120135477

D9S1682

2.33

0.0005

124033322

Region:		120135477-124033322
Phenotype:		ONSET (age at onset of AD)
Name:		17067344
Method:		Linkage
Publication:		Kuo et al. Alcohol Clin Exp Res. (2006) Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. PubMed
Summary:		A 4-cM dense whole-genome linkage study was conducted in the Irish Affected Sib Pair Study of Alcohol Dependence. Probands, affected siblings, and parents were evaluated by structured interview. Variance component linkage analysis was applied to data from 485 families for 5 measures: initial sensitivity and tolerance (based on scales from the self-report of the effects of ethanol; maximum drinks within 24 hours, an empirically derived factor score based on withdrawal symptoms, and age at onset of alcohol dependence.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001735.2	NP_001726.2	NC_000009.10 range: 122754433..122852374, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005579	membrane attack complex	Cellular Component	IEA
GO:0005576	extracellular region	Cellular Component	EXP (3052276)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	TAS (9218605)
GO:0004866	endopeptidase inhibitor activity	Molecular Function	IEA
GO:0005102	receptor binding	Molecular Function	TAS (9590258\|10820279)
GO:0008009	chemokine activity	Molecular Function	TAS (10820279)
GO:0006958	complement activation, classical pathway	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	TAS (8898085)
GO:0000187	activation of MAPK activity	Biological Process	TAS (7649993)
GO:0006957	complement activation, alternative pathway	Biological Process	IEA
GO:0006956	complement activation	Biological Process	IEA
GO:0006954	inflammatory response	Biological Process	TAS (8759757)
GO:0006954	inflammatory response	Biological Process	IEA
GO:0006950	response to stress	Biological Process	TAS (9590258)
GO:0006935	chemotaxis	Biological Process	TAS (10820279)
GO:0019835	cytolysis	Biological Process	IEA