| Gene Information |
| Gene ID: | | 7295 |
| Symbol: | | TXN |
| Full Name: | | thioredoxin |
| Alias: | | DKFZp686B1993|MGC61975|TRX|TRX1 |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 9 |
| Genetic Location: | | 9q31 |
| Physical Location: | | 112046130-112058598 on NC_000009.10, complement |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | AA150817 | | Fold Change: | | 1.5 | | P Value: | | 3.00E-05 | | Tissue: | | Prefrontal cortex |
| | Dataset Information | | Name: | | 15816859 | | Method: | | Microarray | | Tissue: | | Prefrontal cortex and nucleus accumbens | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed | | Summary: | | Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test. |
| | Gene Information | | | Dataset Information | | Name: | | Literature Search | | Method: | | Literature search | | Summary: | | We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005737 | cytoplasm | Cellular Component | IEA | |
| GO:0005829 | cytosol | Cellular Component | EXP (11517226|16750198) | |
| GO:0005515 | protein binding | Molecular Function | IPI (10814541|15480426) | |
| GO:0030508 | thiol-disulfide exchange intermediate activity | Molecular Function | TAS (10947064) | |
| GO:0008283 | cell proliferation | Biological Process | TAS (3170595) | |
| GO:0007267 | cell-cell signaling | Biological Process | TAS (10947064) | |
| GO:0007165 | signal transduction | Biological Process | TAS (10947064) | |
| GO:0006928 | cell motility | Biological Process | TAS (10947064) | |
| GO:0006810 | transport | Biological Process | IEA | |
| GO:0045454 | cell redox homeostasis | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 7295 |
| HGNC: | | 12435 |
| Ensembl: | | ENSG00000136810 |
| MIM: | | 187700 |
| HPRD: | | 01761 |
| HuGE Navigator: | | 7295 |
| dbSNP: | | TXN |
| GeneCard: | | TXN |
| AceView: | | TXN |
