ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

UBB

Full Name:

ubiquitin B

Alias:

FLJ25987|MGC8385

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17p12-p11.2

Physical Location:

16225091-16226778 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 22187 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

UBB

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S1857

16355942

Region:		14355942-18355942
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_018955.2	NP_061828.1	NC_000017.9 range: 16225091..16226778

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IC (14528304)
GO:0005654	nucleoplasm	Cellular Component	EXP (11231585\|11931757\|15029244)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	EXP (9660940\|10995389\|11285280\|11742988\|11931757\|12070128\|12218189\|12593796\|12820959\|15469984\|15781449\|16)
GO:0005515	protein binding	Molecular Function	IPI (14528304)
GO:0030528	transcription regulator activity	Molecular Function	IDA (14528304)
GO:0048167	regulation of synaptic plasticity	Biological Process	TAS (12367500)
GO:0045941	positive regulation of transcription	Biological Process	IDA (14528304)
GO:0042062	long-term strengthening of neuromuscular junction	Biological Process	TAS (12367500)
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	EXP (11285280)
GO:0051436	negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle	Biological Process	EXP (15029244)
GO:0030433	ER-associated protein catabolic process	Biological Process	TAS (11597332)
GO:0016567	protein ubiquitination	Biological Process	IDA (14528304)
GO:0007411	axon guidance	Biological Process	TAS (12367500)
GO:0007049	cell cycle	Biological Process	TAS (12367500)
GO:0006464	protein modification process	Biological Process	IEA
GO:0051437	positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle	Biological Process	EXP (12791267)