ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SUMO1

Full Name:

SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)

Alias:

DAP-1|GMP1|OFC10|PIC1|SENP2|SMT3|SMT3C|SMT3H3|SUMO-1|UBL1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q33

Physical Location:

202779147-202811566 on NC_000002.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

SUMO1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S117

195326948

Region:		195326948-216757195
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	TAS (8806687)
GO:0005643	nuclear pore	Cellular Component	TAS (9019411)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0031965	nuclear membrane	Cellular Component	IEA
GO:0016607	nuclear speck	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IPI (9885291\|12072434\|14516784\|17081985)
GO:0006512	ubiquitin cycle	Biological Process	IEA
GO:0016481	negative regulation of transcription	Biological Process	IDA (15572661)
GO:0016481	negative regulation of transcription	Biological Process	IMP (12072434)
GO:0006464	protein modification process	Biological Process	IEA
GO:0016925	protein sumoylation	Biological Process	IDA (15572661\|15637059)
GO:0006281	DNA repair	Biological Process	TAS (8812453)
GO:0032880	regulation of protein localization	Biological Process	TAS (15637059)
GO:0043433	negative regulation of transcription factor activity	Biological Process	IMP (12072434)