ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

UCK2

Full Name:

uridine-cytidine kinase 2

Alias:

TSA903|UK|UMPK

Organism:

Homo sapiens (Human)

Chromosome:

1

Genetic Location:

1q23

Physical Location:

164063513-164143966 on NC_000001.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D1S2878

163669990

Region:		163669990-165871089
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012474.3	NP_036606.2	NC_000001.9 range: 164063513..164143966

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005829	cytosol	Cellular Component	EXP (11306702)
GO:0005575	cellular_component	Cellular Component	ND
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004849	uridine kinase activity	Molecular Function	IEA
GO:0003674	molecular_function	Molecular Function	ND
GO:0016773	phosphotransferase activity, alcohol group as acceptor	Molecular Function	IEA
GO:0008152	metabolic process	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000143179

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: