ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

UROD

Full Name:

uroporphyrinogen decarboxylase

Alias:

PCT

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1p34

Physical Location:

45250416-45253927 on NC_000001.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 22275 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Gene Information

Original ID1:

UROD

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000374.3	NP_000365.3	NC_000001.9 range: 45250416..45253927

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0004853	uroporphyrinogen decarboxylase activity	Molecular Function	IEA
GO:0004853	uroporphyrinogen decarboxylase activity	Molecular Function	TAS (1634232)
GO:0016829	lyase activity	Molecular Function	IEA
GO:0006779	porphyrin biosynthetic process	Biological Process	IEA
GO:0006783	heme biosynthetic process	Biological Process	IEA