ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Spsb1

Full Name:

splA/ryanodine receptor domain and SOCS box containing 1

Alias:

1110014L01Rik|4930422J18Rik|AI596360|AI854583|MGC102221|SSB-1|SSB1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 E2

Physical Location:

149270391-149329114 on NC_000070.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 80176 Symbol (Name): SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1)

Ortholog Status:

The human GeneID 80176 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AI596360
Fold Change:		2.3, 1.4, 2.0, 1.9
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_029035.2	NP_083311.1	NC_000070.5 range: 149270391..149329114, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0006512	ubiquitin cycle	Biological Process	IEA
GO:0007242	intracellular signaling cascade	Biological Process	RCA (16141072)