ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

XRCC4

Full Name:

X-ray repair complementing defective repair in Chinese hamster cells 4

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

5q13-q14

Physical Location:

82409072-82685334 on NC_000005.8

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

XRCC4

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

Original ID	No. of Publications	Phenotype
XRCC4	1	Alcoholism

HuGE Navigator Dataset

Name:		HuGE Navigator
Method:		Literature data mining
Publication:		Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:		HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000793	condensed chromosome	Cellular Component	IDA (12589063)
GO:0005634	nucleus	Cellular Component	IDA (9259561\|12589063)
GO:0005634	nucleus	Cellular Component	NAS (16439205)
GO:0005829	cytosol	Cellular Component	IDA (9259561)
GO:0005958	DNA-dependent protein kinase complex	Cellular Component	IDA (15194694)
GO:0032807	DNA ligase IV complex	Cellular Component	IDA (9242410)
GO:0008022	protein C-terminus binding	Molecular Function	IPI (9259651)
GO:0016874	ligase activity	Molecular Function	IDA (9242410)
GO:0003677	DNA binding	Molecular Function	IDA (9259561)
GO:0019059	initiation of viral infection	Biological Process	EXP (12091904)
GO:0019047	provirus integration	Biological Process	EXP (16291214)
GO:0051103	DNA ligation during DNA repair	Biological Process	IDA (12517771)
GO:0010165	response to X-ray	Biological Process	IDA (9242410)
GO:0006303	double-strand break repair via nonhomologous end joining	Biological Process	NAS (16439205)
GO:0006303	double-strand break repair via nonhomologous end joining	Biological Process	IMP (9809069)
GO:0006303	double-strand break repair via nonhomologous end joining	Biological Process	IDA (12517771)
GO:0051351	positive regulation of ligase activity	Biological Process	IDA (9242410)