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Gene Information
Gene ID:7529
Full Name:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
Organism:Homo sapiens (Human)
Genetic Location:20q13.1
Physical Location:42947757-42970574 on NC_000020.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AL008725
Fold Change:1.4, 1.4
Note:Differential Expression on the cDNA array (two fold changes are from two case groups)
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Linkage Dataset
MarkerLODP valueLocation (bp)
D20S119  43082264
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_003404.3NP_003395.1NC_000020.9 range: 42947757..42970574
NM_139323.2NP_647539.1NC_000020.9 range: 42947757..42970574
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIDA (12963375)
GO:0005829cytosolCellular ComponentEXP (9069260|10195903|12657644)
GO:0042470melanosomeCellular ComponentIEA
GO:0048471perinuclear region of cytoplasmCellular ComponentIDA (12963375)
GO:0004497monooxygenase activityMolecular FunctionIEA
GO:0019904protein domain specific bindingMolecular FunctionIEA
GO:0007265Ras protein signal transductionBiological ProcessEXP (11520933)
GO:0008633activation of pro-apoptotic gene productsBiological ProcessEXP (15231831)
Other Database Cross Links
NCBI Entrez Gene:7529
HuGE Navigator:7529