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Gene Information
Gene ID:7533
Symbol:YWHAH
Full Name:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
Alias:YWHA1
Organism:Homo sapiens (Human)
Chromosome:22
Genetic Location:22q12.3
Physical Location:30670478-30683589 on NC_000022.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:YWHAH
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original ID1:AA127798
Fold Change:0.68
P Value:0.02
Tissue:Nucleus accumbens
Dataset Information
Name:15816859
Method:Microarray
Tissue:Prefrontal cortex and nucleus accumbens
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_003405.3NP_003396.1NC_000022.9 range: 30670478..30683589
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentISS
GO:0003779actin bindingMolecular FunctionISS
GO:0035259glucocorticoid receptor bindingMolecular FunctionIPI (9079630)
GO:0019904protein domain specific bindingMolecular FunctionISS
GO:0016563transcription activator activityMolecular FunctionIDA (15790729)
GO:0005159insulin-like growth factor receptor bindingMolecular FunctionISS
GO:0006886intracellular protein transportBiological ProcessISS
GO:0006713glucocorticoid catabolic processBiological ProcessIDA (15790729)
GO:0042921glucocorticoid receptor signaling pathwayBiological ProcessIDA (15790729)
GO:0045664regulation of neuron differentiationBiological ProcessISS
GO:0045941positive regulation of transcriptionBiological ProcessIDA (15790729)
GO:0048167regulation of synaptic plasticityBiological ProcessISS
GO:0050774negative regulation of dendrite morphogenesisBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:7533
HGNC:12853
Ensembl:ENSG00000128245
MIM:113508
HPRD:00215
HuGE Navigator:7533
dbSNP:YWHAH
GeneCard:YWHAH
AceView:YWHAH