ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

YWHAH

Full Name:

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide

Alias:

YWHA1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

22q12.3

Physical Location:

30670478-30683589 on NC_000022.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

YWHAH

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003405.3	NP_003396.1	NC_000022.9 range: 30670478..30683589

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0003779	actin binding	Molecular Function	ISS
GO:0035259	glucocorticoid receptor binding	Molecular Function	IPI (9079630)
GO:0019904	protein domain specific binding	Molecular Function	ISS
GO:0016563	transcription activator activity	Molecular Function	IDA (15790729)
GO:0005159	insulin-like growth factor receptor binding	Molecular Function	ISS
GO:0006886	intracellular protein transport	Biological Process	ISS
GO:0006713	glucocorticoid catabolic process	Biological Process	IDA (15790729)
GO:0042921	glucocorticoid receptor signaling pathway	Biological Process	IDA (15790729)
GO:0045664	regulation of neuron differentiation	Biological Process	ISS
GO:0045941	positive regulation of transcription	Biological Process	IDA (15790729)
GO:0048167	regulation of synaptic plasticity	Biological Process	ISS
GO:0050774	negative regulation of dendrite morphogenesis	Biological Process	ISS