ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Dok5

Full Name:

docking protein 5

Alias:

2700055C10Rik

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 H3|2 99.0 cM

Physical Location:

170557439-170705267 on NC_000068.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 55816 Symbol (Name): DOK5 (docking protein 5)

Ortholog Status:

The human GeneID 55816 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

Dok5

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_029761.3	NP_084037.2	NC_000068.6 range: 170557439..170705267

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0005066	transmembrane receptor protein tyrosine kinase signaling protein activity	Molecular Function	IPI (11470823)
GO:0005158	insulin receptor binding	Molecular Function	IEA
GO:0000165	MAPKKK cascade	Biological Process	IDA (11470823)
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	IPI (11470823)
GO:0007399	nervous system development	Biological Process	IDA (11470823)