ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

FZD5

Full Name:

frizzled homolog 5 (Drosophila)

Alias:

C2orf31|DKFZP434E2135|HFZ5|MGC129692

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q33-q34

Physical Location:

208335554-208342387 on NC_000002.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 14367 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S117

195326948

Region:		195326948-216757195
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003468.3	NP_003459.2	NC_000002.10 range: 208335554..208342387, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000139	Golgi membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	TAS (9054360)
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0004930	G-protein coupled receptor activity	Molecular Function	IEA
GO:0004926	non-G-protein coupled 7TM receptor activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	TAS (9054360)
GO:0007164	establishment of tissue polarity	Biological Process	TAS (8626800)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0016055	Wnt receptor signaling pathway	Biological Process	IEA