ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ST8SIA4

Full Name:

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

Alias:

MGC34450|MGC61459|PST|PST1|SIAT8D|ST8SIA-IV

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

5q21

Physical Location:

100170802-100266868 on NC_000005.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D5S644

95838450

Region:		95838450-103990852
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000139	Golgi membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0030173	integral to Golgi membrane	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0008373	sialyltransferase activity	Molecular Function	TAS (10766765)
GO:0008373	sialyltransferase activity	Molecular Function	IEA
GO:0007399	nervous system development	Biological Process	TAS (9054414)
GO:0006491	N-glycan processing	Biological Process	TAS (10766765)
GO:0009311	oligosaccharide metabolic process	Biological Process	TAS (10766765)
GO:0006486	protein amino acid glycosylation	Biological Process	IEA