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Gene Information
Gene ID:79114
Full Name:Fibroblast growth factor receptor 1
Organism:Rattus norvegicus (Rat)
Genetic Location:16q12.4
Physical Location:70869973-70910044 on NC_005115.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 2260    Symbol (Name): FGFR1 (fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome))
Ortholog Status:The human GeneID 2260 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Fgfr1
Fold Change:-1.21
Dataset Information
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_024146.1NP_077060.1NC_005115.2 range: 70869973..70910044, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0008201heparin bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005007fibroblast growth factor receptor activityMolecular FunctionTAS (9763444)
GO:0004872receptor activityMolecular FunctionIEA
GO:0004714transmembrane receptor protein tyrosine kinase activityMolecular FunctionIEA
GO:0004713protein-tyrosine kinase activityMolecular FunctionIEA
GO:0048754branching morphogenesis of a tubeBiological ProcessISS
GO:0048699generation of neuronsBiological ProcessISS
GO:0048514blood vessel morphogenesisBiological ProcessISS
GO:0031175neurite developmentBiological ProcessIDA (12791257)
GO:0042127regulation of cell proliferationBiological ProcessIDA (9763444)
GO:0048469cell maturationBiological ProcessISS
GO:0042127regulation of cell proliferationBiological ProcessISS
GO:0042472inner ear morphogenesisBiological ProcessISS
GO:0043066negative regulation of apoptosisBiological ProcessISS
GO:0030326embryonic limb morphogenesisBiological ProcessISS
GO:0030324lung developmentBiological ProcessISS
GO:0001525angiogenesisBiological ProcessISS
GO:0001759induction of an organBiological ProcessISS
GO:0002053positive regulation of mesenchymal cell proliferationBiological ProcessISS
GO:0002062chondrocyte differentiationBiological ProcessISS
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0007420brain developmentBiological ProcessISS
GO:0007435salivary gland morphogenesisBiological ProcessISS
GO:0008284positive regulation of cell proliferationBiological ProcessISS
GO:0008543fibroblast growth factor receptor signaling pathwayBiological ProcessISS
GO:0060045positive regulation of cardiac muscle cell proliferationBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:79114