ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

79114

Symbol:

Fgfr1

Full Name:

Fibroblast growth factor receptor 1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

16q12.4

Physical Location:

70869973-70910044 on NC_005115.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2260 Symbol (Name): FGFR1 (fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome))

Ortholog Status:

The human GeneID 2260 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Fgfr1
Fold Change:		-1.21
Tissue:		Amygdala

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_024146.1	NP_077060.1	NC_005115.2 range: 70869973..70910044, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0008201	heparin binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0005007	fibroblast growth factor receptor activity	Molecular Function	TAS (9763444)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function	IEA
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0048754	branching morphogenesis of a tube	Biological Process	ISS
GO:0048699	generation of neurons	Biological Process	ISS
GO:0048514	blood vessel morphogenesis	Biological Process	ISS
GO:0031175	neurite development	Biological Process	IDA (12791257)
GO:0042127	regulation of cell proliferation	Biological Process	IDA (9763444)
GO:0048469	cell maturation	Biological Process	ISS
GO:0042127	regulation of cell proliferation	Biological Process	ISS
GO:0042472	inner ear morphogenesis	Biological Process	ISS
GO:0043066	negative regulation of apoptosis	Biological Process	ISS
GO:0030326	embryonic limb morphogenesis	Biological Process	ISS
GO:0030324	lung development	Biological Process	ISS
GO:0001525	angiogenesis	Biological Process	ISS
GO:0001759	induction of an organ	Biological Process	ISS
GO:0002053	positive regulation of mesenchymal cell proliferation	Biological Process	ISS
GO:0002062	chondrocyte differentiation	Biological Process	ISS
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0007420	brain development	Biological Process	ISS
GO:0007435	salivary gland morphogenesis	Biological Process	ISS
GO:0008284	positive regulation of cell proliferation	Biological Process	ISS
GO:0008543	fibroblast growth factor receptor signaling pathway	Biological Process	ISS
GO:0060045	positive regulation of cardiac muscle cell proliferation	Biological Process	ISS