ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PGAP1

Full Name:

post-GPI attachment to proteins 1

Alias:

Bst1|FLJ42774|ISPD3024

Organism:

Homo sapiens (Human)

Chromosome:

2

Genetic Location:

2q33.1

Physical Location:

197405972-197499698 on NC_000002.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S117

195326948

Region:		195326948-216757195
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_024989.3	NP_079265.2	NC_000002.10 range: 197405972..197499698, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005783	endoplasmic reticulum	Cellular Component	ISS
GO:0031227	intrinsic to endoplasmic reticulum membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0004518	nuclease activity	Molecular Function	ISS
GO:0042578	phosphoric ester hydrolase activity	Molecular Function	ISS
GO:0015798	myo-inositol transport	Biological Process	ISS
GO:0006886	intracellular protein transport	Biological Process	IEA
GO:0016255	attachment of GPI anchor to protein	Biological Process	EXP (1846368)
GO:0006505	GPI anchor metabolic process	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000197121

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: