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Gene Information
Gene ID:80198
Symbol:MUS81
Full Name:MUS81 endonuclease homolog (S. cerevisiae)
Alias:FLJ21012|FLJ44872
Organism:Homo sapiens (Human)
Chromosome:11
Genetic Location:11q13
Physical Location:65384447-65390489 on NC_000011.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:N99229
Fold Change:1.69
P Value:7.00E-03
Tissue:Prefrontal cortex
Dataset Information
Name:15816859
Method:Microarray
Tissue:Prefrontal cortex and nucleus accumbens
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_025128.4NP_079404.3NC_000011.8 range: 65384447..65390489
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005622intracellularCellular ComponentIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0000287magnesium ion bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0004519endonuclease activityMolecular FunctionIEA
GO:0004518nuclease activityMolecular FunctionIEA
GO:0003677DNA bindingMolecular FunctionIEA
GO:0043565sequence-specific DNA bindingMolecular FunctionIEA
GO:0006259DNA metabolic processBiological ProcessIEA
GO:0006281DNA repairBiological ProcessIEA
GO:0006310DNA recombinationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:80198
HGNC:29814
Ensembl:ENSG00000172732
MIM:606591
HPRD:09419
HuGE Navigator:80198
dbSNP:MUS81
GeneCard:MUS81
AceView:MUS81