ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Med8

Full Name:

mediator of RNA polymerase II transcription, subunit 8 homolog (yeast)

Alias:

2210021A15Rik|AB041805|ARC32|MNCb-2386

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 D1

Physical Location:

118081941-118088386 on NC_000070.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 112950 Symbol (Name): MED8 (mediator complex subunit 8)

Ortholog Status:

The human GeneID 112950 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

Med8

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000119	mediator complex	Cellular Component	ISS (14638676)
GO:0005634	nucleus	Cellular Component	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006512	ubiquitin cycle	Biological Process	IEA