ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ILKAP

Full Name:

integrin-linked kinase-associated serine/threonine phosphatase 2C

Alias:

DKFZP434J2031|FLJ10181|MGC4846|PP2C-DELTA

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q37.3

Physical Location:

238743781-238777062 on NC_000002.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S2973

2.20

0.0007

235696080

D2S140

1.95

0.0014

241388318

Region:		235696080-241388318
Phenotype:		WDSFS (withdrawal symptoms factor score)
Name:		17067344
Method:		Linkage
Publication:		Kuo et al. Alcohol Clin Exp Res. (2006) Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. PubMed
Summary:		A 4-cM dense whole-genome linkage study was conducted in the Irish Affected Sib Pair Study of Alcohol Dependence. Probands, affected siblings, and parents were evaluated by structured interview. Variance component linkage analysis was applied to data from 485 families for 5 measures: initial sensitivity and tolerance (based on scales from the self-report of the effects of ethanol; maximum drinks within 24 hours, an empirically derived factor score based on withdrawal symptoms, and age at onset of alcohol dependence.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_030768.2	NP_110395.1	NC_000002.10 range: 238743781..238777062, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0008287	protein serine/threonine phosphatase complex	Cellular Component	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0004722	protein serine/threonine phosphatase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0030145	manganese ion binding	Molecular Function	IEA
GO:0006470	protein amino acid dephosphorylation	Biological Process	IEA