ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Celsr2

Full Name:

cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)

Alias:

Megf3

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q34

Physical Location:

203959080-203983132 on NC_005101.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1952 Symbol (Name): CELSR2 (cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila))

Ortholog Status:

The human GeneID 1952 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_001076220.1	XP_001076220.1	NC_005101.2 range: 203959080..203983132, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0004930	G-protein coupled receptor activity	Molecular Function	IEA
GO:0022407	regulation of cell-cell adhesion	Biological Process	IMP
GO:0021999	neural plate anterioposterior pattern formation	Biological Process	ISS
GO:0016055	Wnt receptor signaling pathway	Biological Process	ISS
GO:0032583	regulation of gene-specific transcription	Biological Process	ISS
GO:0007283	spermatogenesis	Biological Process	IEP (10650949)
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0007218	neuropeptide signaling pathway	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0007156	homophilic cell adhesion	Biological Process	IEA
GO:0048813	dendrite morphogenesis	Biological Process	IMP