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Gene Information
Gene ID:84203
Symbol:TXNDC2
Full Name:thioredoxin domain-containing 2 (spermatozoa)
Alias:DKFZp434H0311|MGC35026|SPTRX|SPTRX1
Organism:Homo sapiens (Human)
Chromosome:18
Physical Location:9875361-9878155 on NC_000018.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D18S53  11482730
Region:9482730-13482730
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001098529.1NP_001091999.1NC_000018.8 range: 9875361..9878155
NM_001098530.1NP_001092000.1NC_000018.8 range: 9875361..9878155
NM_032243.5NP_115619.4NC_000018.8 range: 9875361..9878155
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIDA (11399755)
GO:0005737cytoplasmCellular ComponentISS
GO:0004791thioredoxin-disulfide reductase activityMolecular FunctionIDA (11399755)
GO:0004791thioredoxin-disulfide reductase activityMolecular FunctionISS
GO:0007275multicellular organismal developmentBiological ProcessIEA
GO:0007283spermatogenesisBiological ProcessNAS (11399755)
GO:0030154cell differentiationBiological ProcessIEA
GO:0045454cell redox homeostasisBiological ProcessIEA
GO:0045454cell redox homeostasisBiological ProcessNAS (11399755)
Other Database Cross Links
NCBI Entrez Gene:84203
HGNC:16470
Ensembl:ENSG00000168454
MIM:
HPRD:11654
HuGE Navigator:84203
dbSNP:TXNDC2
GeneCard:TXNDC2
AceView:TXNDC2